glycogen synthase kinase-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9987	GSK3-IN-1		GSK-3
	GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.		GSK-3
T1965	Bikinin	Abrasin	Others , GSK-3
	Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.		Others , GSK-3
T10202	A 1070722		GSK-3
	A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for...		GSK-3
T5956	VP3.15 dihydrobromide		GSK-3 , PDE
	VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.)		GSK-3 , PDE
T1755	LY2090314		GSK-3
	LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a...		GSK-3
T1957	AZD2858		GSK-3
	AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.		GSK-3
T1741	AZD1080		GSK-3
	AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.		GSK-3
T2166	TWS119		GSK-3 , Autophagy
	TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation		GSK-3 , Autophagy
T9611	PF-04802367		GSK-3
	PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ...		GSK-3
T2261	IM-12	IM 12	GSK-3
	IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.		GSK-3
T3077	SB 216763	SB216763	GSK-3 , Autophagy
	SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).		GSK-3 , Autophagy
T3684	CP21R7	CP21	GSK-3 , PKC
	CP21R7 (CP21) is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth muscle and endothelial cells. CP21R7 can be combined ...		GSK-3 , PKC
T21966	MeBIO		GSK-3 , Aryl Hydrocarbon Receptor , CDK
	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.		GSK-3 , Aryl Hydrocarbon Receptor , CDK
T14066	9-ING-41		Apoptosis , GSK-3 , Autophagy
	9-ING-41 is a glycogen synthase kinase-3 inhibitor.		Apoptosis , GSK-3 , Autophagy
T12664	(Rac)-BRD0705		Others
	(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.		Others
T10606	BRD0705		GSK-3
	BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).		GSK-3
T11447	GNF4877		GSK-3 , DYRK
	GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation cells.		GSK-3 , DYRK
T3074	CHIR 98024	CHIR98014	GSK-3 , S6 Kinase
	CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.		GSK-3 , S6 Kinase
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T9138	Indirubin-3′-oxime	Indirubin-3'-monoxime	GSK-3 , CDK , JNK
	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.		GSK-3 , CDK , JNK